Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results from Two Prospective Cohorts
- Brian H. Chen, MPH1,
- Yiqing Song, MD,ScD (ysong3{at}rics.bwh.harvard.edu)2,
- Eric L. Ding3,4,
- Christian K. Roberts, PhD1,5,
- JoAnn E. Manson, MD,DrPH2,3,
- Nader Rifai, PhD6,
- Julie E. Buring, ScD2,3,7,
- J. Michael Gaziano, MD2,8 and
- Simin Liu, MD,ScD (siminliu{at}ucla.edu)1,9
- 1Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA
- 2Division of Preventive Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA
- 3Department of Epidemiology, Harvard School of Public Health, Boston, MA
- 4Department of Nutrition, Harvard School of Public Health, Boston, MA
- 5Department of Physiological Science, University of California, Los Angeles, CA
- 6Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, MA
- 7Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA
- 8Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
- 9 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA
Abstract
Objective: To investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women.
Research design and methods: We conducted two prospective case-control studies nested in the Women's Health Study (WHS) and Physicians' Health Study II (PHS II). In the WHS, during a median of 10-years follow-up, 359 postmenopausal women apparently healthy at baseline, who later developed type 2 diabetes, were prospectively matched with 359 healthy controls. In the PHS II, with 8 years total follow-up, 170 men apparently healthy at baseline, who later developed type 2 diabetes, were matched with 170 healthy controls. Controls were matched by age, race, and time of blood draw.
Results: Resistin levels at baseline were significantly higher in women than in men (p<0.001) and in cases than controls in both women (p<0.001) and men (p=0.07). After adjustment for matching factors, physical activity, alcohol intake, smoking, and family history of diabetes, the RR of type 2 diabetes comparing the highest to the lowest quartile of resistin in women was 2.23 (95%CI=1.33-3.75; ptrend=0.002). This association was attenuated after further adjusting for BMI (RR=1.51, 95%CI=0.86-2.65; ptrend=0.21) or CRP (RR=1.19, 95%CI=0.68-2.09; ptrend=0.59). A similar yet weaker pattern was observed in men.
Conclusions: Elevated levels of circulating resistin were significantly related to increased risk of type 2 diabetes, which appears to be partially accounted for by adiposity and the inflammatory process.
Footnotes
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- Received September 3, 2008.
- Accepted October 21, 2008.
- Copyright © American Diabetes Association
