RANDOM CAPILLARY BLOOD GLUCOSE CUT POINTS FOR DIABETES AND PRE-DIABETES DERIVED FROM COMMUNITY BASED OPPORTUNISTIC SCREENING IN INDIA
- Suresh Somannavar, Md,
- Anbazhagan Ganesan, B.Sc,
- Mohan Deepa, M.Sc., Ph.D.,
- Manjula Datta, Md, Dch, M.Sc., FRCP and
- Viswanathan Mohan, Md.,Frcp., Ph.D., D.Sc. (drmohans{at}vsnl.net)
- 1Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India
Abstract
Aim: To determine random capillary blood glucose (RCBG) cut points which discriminate diabetic and pre-diabetic subjects from normal individuals.
Methods: RCBG was done in 1,333 individuals randomly chosen from 63,305 who had participated in an opportunistic screening program. OGTT was also done by venous plasma glucose on autoanalyser. RCBG cut points which discriminate diabetes, impaired glucose tolerance and impaired fasting glucose were determined using Receiver Operating Characteristic (ROC) curves.
Results: Using the 2HrPG≥200mg/dl (11.1mmol/L) criterion, the RCBG cut point of 140mg/dl (7.7mmol/l) gave the highest sensitivity and specificity. For the 2HrPG≥200mg/dl (11.1mmol/L) values and FPG≥126mg/dl (7.0mmol/L) criterion, either 2HrPG≥200mg/dl (11.1mmol/L) or FPG≥126mg/dl (7.0mmol/L) criterion, and the FPG≥126mg/dl (7.0mmol/L) criterion, RCBG cut point was 143 mg/dl (7.9mmol/L). Respective RCBG cut points for IGT, IFG(WHO) and IFG(ADA) criteria were 119mg/dl (6.6mmol/L), 118mg/dl (6.6mmol/L) and 113mg/dl (6.3mmol/L).
Conclusion: In Asian Indians, those with RCBG>110 mg/dl on screening, can be recommended to undergo definitive testing.
Footnotes
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- Received February 26, 2008.
- Accepted November 28, 2008.
- Copyright © American Diabetes Association
