Lower serum creatinine is a new risk factor of type 2 diabetes: The Kansai Healthcare Study
- Nobuko Harita, M.D.1,
- Tomoshige Hayashi, M.D., PhD. (thayashi{at}med.osaka-cu.ac.jp)1,
- Kyoko Kogawa Sato, M.D., PhD.1,
- Yoshiko Nakamura, M.D., PhD.2,
- Takeshi Yoneda, M.D.1,
- Ginji Endo, M.D., PhD.1 and
- Hiroshi Kambe, M.D.1,2
- 1.Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan
- 2.Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation
Abstract
Objective: As skeletal muscle is one of the target organs for insulin, skeletal muscle mass might be associated with type 2 diabetes. Serum creatinine is a possible surrogate marker of skeletal muscle mass. It is not known whether the serum creatinine level is associated with type 2 diabetes.
Research design and methods: Study participants were 8,570 non-diabetic Japanese men aged 40–55 years at entry. Type 2 diabetes was diagnosed if the fasting plasma glucose level was ≥126 mg/dL or if participants were taking oral hypoglycemic medication or insulin.
Results: During 4-year follow-up, 877 men developed type 2 diabetes. Lower serum creatinine was associated with an increased risk of type 2 diabetes. The multiple-adjusted odds ratio for those who had serum creatinine level of 0.40–0.60 mg/dL was 1.91 (95% CI 1.44–2.54) compared to those with 0.71–0.80 mg/dL.
Conclusions: Lower serum creatinine increased the risk of type 2 diabetes.
Footnotes
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- Received July 9, 2008.
- Accepted November 24, 2008.
- Copyright © American Diabetes Association
