Serum Monocyte Chemoattractant Protein-1 (MCP-1) Concentrations Associate with Diabetes Status but not Arterial Stiffness in Children with Type 1 Diabetes
- Issam Zineh, PharmD1,
- Amber L. Beitelshees, PharmD, MPH1,
- Janet H. Silverstein, MD2 and
- Michael J. Haller, MD, MS (hallemj{at}peds.ufl.edu)2
- 1Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL USA
- 2Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida College of Medicine
Abstract
Objective: The relationship between circulating markers of inflammation and arterial stiffness in children with type 1 diabetes (T1D) is not well-studied. We tested whether inflammatory MCP-1 concentrations correlate with arterial stiffness or T1D status.
Research Design and Methods: MCP-1 concentrations and radial tonometry data were available for 98 children with T1D and 55 healthy controls. Arterial stiffness was calculated as heart rate-corrected augmentation index (AI75). Correlation between MCP-1 and AI75, and differences in MCP-1 concentrations between cases and controls were tested.
Results: MCP-1 was significantly higher in children with T1D than controls (p<0.001). However, there were no correlations between MCP-1 and AI75 in the overall sample or upon stratification by T1D status (range p=0.28-0.66).
Conclusion: Circulating MCP-1 was not associated with arterial stiffness but was significantly elevated in children with T1D, indicating a pro-inflammatory state as young as 10 years. The clinical significance MCP-1 elevation in T1D needs further investigation.
Footnotes
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- Received October 10, 2008.
- Accepted December 2, 2008.
- Copyright © American Diabetes Association
