Influence of adiponectin gene polymorphisms on adiponectin level and insulin resistance index in response to dietary intervention in overweight-obese patients with impaired fasting glucose or newly diagnosed type 2 diabetes

  1. Hye Kyung Chung, RD, PhD1,2,
  2. Jey Sook Chae, PhD2,3,
  3. Yae Jung Hyun, PhD2,3,
  4. Jean Kyung Paik, MS2,4,
  5. Ji Young Kim, PhD2,3,
  6. Yangsoo Jang, MD, PhD, FACC3,5,6,
  7. Hyuck Moon Kwon, MD, PhD7,
  8. Young Duk Song, MD8,
  9. Hyun Chul Lee, MD, PhD9 and
  10. Jong Ho Lee, PhD, RD (jhleeb{at}yonsei.ac.kr)2,3,4
  1. 1Department of Nutrition Services, Youngdong Severance Hospital, Seoul, Korea
  2. 2National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Dept. of Food and Nutrition, College of Human Ecology, Yonsei Univ., Seoul, Korea
  3. 3Yonsei University Research Institute of Science for Aging, Yonsei Univ
  4. 4Dept. of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei Univ
  5. 5Cardiovascular Genome Center, Yonsei Univ. College of Medicine
  6. 6Cardiology Division, Cardiovascular Center, Yonsei Univ. College of Medicine
  7. 7Department of Cardiology and Cardiovascular center, Yongdong Severance Hospital
  8. 8Department of Endocrinology and Metabolism, National Health Insurance Cooperation Ilsan Hospital, Kyungki Province, Korea
  9. 9Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei Univ. College of Medicine

    Abstract

    Objective: This study aimed to determine the effect of common adiponectin gene polymorphisms on dietary intervention-mediated changes in adiponectin levels and homeostasis model assessed-insulin resistance (HOMA-IR) indices.

    Research Design and Methods: A total of 363 subjects with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes followed a dietary intervention (replacement of cooked refined rice with whole grains and increase in vegetable intake) and regular walking for 12 weeks without any medication. Adiponectin gene single-nucleotide polymorphisms [(SNPs) 45, 276, and -11377] were examined in these subjects.

    Results: Following this dietary intervention, fasting glucose levels decreased in all three SNP45T>G genotype groups. Subjects with the SNP45 TT genotype showed increased adiponectin levels and decreased HOMA-IR indices. Haplotype analysis revealed that homozygous carriers of the TG haplotype (45TT and 276GG) and heterozygous carriers of the TG haplotype (TG/X) showed a reduction in the HOMA-IR index after adjustment for baseline levels. Significant differences were observed in changes in HOMA-IR indices and adiponectin concentrations according to the 45-276 TG haplotype in overweight-obese, but not in normal-weight subjects: the greatest decrease in HOMA-IR indices and the greatest increase in adiponectin levels were shown in overweight-obese subjects with the TG/TG haplotype.

    Conclusions: ADIPOQ genetic variants can affect circulating adiponectin levels and insulin resistance indices in subjects with IFG or newly diagnosed type 2 diabetes in response to dietary intervention.

    Footnotes

      • Received November 10, 2008.
      • Accepted January 3, 2009.

    This Article

    1. Published online before print January 8, 2009, doi: 10.2337/dc08-1605
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