Obesity and Albuminuria Among Adults with Type 2 Diabetes: The Look AHEAD (Action for Health in Diabetes) Study

  1. Holly Kramer, MD, MPH (hkramer{at}lumc.edu)1,
  2. David Reboussin, PhD2,
  3. Alain Bertoni, MD3,
  4. Santica Marcovina, PhD, ScD4,
  5. Edward Lipkin, MD, PhD5 and
  6. Frederick L. Brancati, MD, MHS6
  1. 1Dept. Preventive Medicine and Epidemiology and Medicine, Division of Nephrology and Hypertension, Loyola University Medical Center, Maywood, IL
  2. 2Department of Biostatistical Sciences, and
  3. 3Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC
  4. 4Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, Seattle, WA
  5. 5Department of Medicine, Division of Metabolism and Endocrinology, University of Washington and VA Puget Sound Health Care System, Seattle, WA
  6. 6Departments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, MD And the Look AHEAD Research Group

    Abstract

    Objective: To determine the association between obesity measures and albuminuria in adults with type 2 diabetes.

    Research Design and Methods: Among participants of the Look AHEAD (Action for Health in Diabetes) Study, body mass index (BMI) and waist circumference were measured in 4985 while total percent body fat was measured by whole-body DEXA scans among 1351 participants. Odds of albuminuria by quartiles of BMI, waist circumference and percent total body fat were calculated using logistic regression while adjusting for covariates.

    Results: The highest quartile of BMI (OR 1.72; 95% CI 1.40, 2.11) and waist circumference (OR 1.75; 95% CI 1.42, 2.15) was significantly associated with albuminuria compared to the lowest quartile after adjustment for covariates. No association was noted between quartiles of percent total body fat and albuminuria in any model.

    Conclusions: Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.

    Footnotes

      • Received November 14, 2008.
      • Accepted January 24, 2009.

    This Article

    1. Published online before print February 5, 2009, doi: 10.2337/dc08-2059
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