Cardiovascular risk attributable to diabetes mellitus in southern Brazil: a population-based cohort study
- Leila B. Moreira, MD, PhD (lbmoreira{at}hcpa.ufrgs.br)1,
- Sandra C. Fuchs, MD, PhD2,
- Mário Wiehe, MD, PhD3,
- Jeruza L. Neyeloff3,
- Rafael Picon3,
- Marina B. Moreira3,
- Miguel Gus3 and
- Flávio D. Fuchs, MD, PhD3
- 1Departments of Pharmacology and
- of 2Social Medicine, School of Medicine, Universidade Federal do Rio Grande do Sul, Brazil
- Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil
Abstract
Objectives: To analyze the impact of diabetes mellitus (DM) on general and cardiovascular disease (CVD) mortality and morbidity in Southern Brazil.
Research design and methods: Population-based cohort study of 1091 individuals. DM was ascertained by medical history. Vital status of 982 individuals and incidence of events were ascertained in another visit and through hospital records, death certificates and verbal necropsy with relatives.
Results: Participants were 43.1 ± 0.9 years old and 55.7% were women. The prevalence of DM was 4.2% and the mean follow-up time was 5.3 ± 0. 07 years; mortality was 36.3% and 6.6%, respectively in participants with and without DM; the incidence of CVD was 20.8% and 3.0%, with an adjusted HR of 4.4 (95% CI 2.4-7.9). DM population-attributable risk for CVD mortality was 10.1% and for total CVD was 13.1%.
Conclusion: DM is responsible for large population-attributable risk for overall mortality and cardiovascular events in Brazil.
Footnotes
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- Received October 28, 2008.
- Accepted February 10, 2009.
- Copyright © American Diabetes Association
