Effect of drinking on adiponectin in healthy men and women: A randomised intervention study of water, ethanol, red wine and beer with or without alcohol.

Abstract

Objective: Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations but effects might be differ according to gender and beverage consumed.

Research design and methods: Seventy-two healthy individuals (22-56 years) were enrolled in this randomised controlled cross-over trial. After wash-out, two interventions for 3 weeks followed: ethanol (concentration 12.5 %), beer (5.6 %), or red wine (12.5 %) equivalent to 30 grams of ethanol per day for men and 20 g/d for women or the same de-alcoholised beverages, or water. Adiponectin was measured by sandwich ELISA.

Results: Among females adiponectin significantly increased after with red wine (29,8% p<0.05), among men after ethanol solution (17.4%, p<0.05) and beer (16.1%, p<0.05). De-alcoholised beverages had no substantial effect on adiponectin concentrations.

Conclusion: Moderate amounts of ethanol-containing beverages increased adiponectin concentrations but gender specific effects might depend on type of beverage consumed.