Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: the Multi-Ethnic Study of Atherosclerosis.
- Laura A Colangelo, MS (l-colangelo{at}northwestern.edu),
- Pamela Ouyang, MD,
- Kiang Liu, PhD,
- Peter Kopp, MD,
- Sherita Hill Golden, MD,
- Adrian S Dobs, MD,
- Moyses Szklo, MD, DrPH,
- Dhananjay Vaidya, PhD, MPH,
- Mary Cushman, MD and
- Susan M Gapstur, PhD
- Departments of Medicine (PO, SHG, ASD, DV) and Epidemiology (SHG, MS), Johns Hopkins University, Baltimore, Maryland Divisions of Endocrinology, Metabolism and Molecular Medicine (PK) and Department of Preventive Medicine (LAC, KL, SMG), Feinberg School of Medicine, Northwestern University, Chicago, Illinois Department of Medicine (MC), University of Vermont, Burlington, Vermont
Abstract
Objective: Assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men.
Research design and methods: Included were 3156 African American, Non-Hispanic white, Hispanic and Chinese American men aged 45-84 years who participated in the baseline visit of the Multi-Ethnic Study of Atherosclerosis. Odds ratios and 95% CIs for type 2 diabetes and IFG compared to normal fasting glucose for quartiles of hormones were estimated.
Results: After adjusting for age, ethnicity, BMI, and waist circumference, IFG and diabetes were associated inversely with total testosterone (T) and sex hormone binding globulin (SHBG), and positively with estradiol (E2). DHEA was positively associated with IFG, but not with diabetes. Associations did not differ across ethnic groups.
Conclusions: Regardless of obesity, total T and SHBG were associated inversely, and E2 positively with IFG and diabetes in men. Further research is warranted to better understand the underlying biologic mechanisms.
Footnotes
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- Received December 11, 2008.
- Accepted March 5, 2009.
- Copyright © American Diabetes Association
