TRIB3 Functional Q84R Polymorphism is a Risk Factor for Metabolic Syndrome and Carotid Atherosclerosis
- Hui-ping Gong, MD,
- Zhi-hao Wang, MD,
- Hao Jiang, MD,
- Ning-ning Fang, MD,
- Ji-sheng Li, PhD,
- Yuan-yuan Shang, MD,
- Yun Zhang, MD,
- Ming Zhong, MD (zhongmingzm{at}gmail.com) and
- Wei Zhang, MD (zhangweisdu{at}gmail.com)
- Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan 250012, P.R.China
Abstract
Objective: To determine the association of TRIB3 Q84R polymorphism with metabolic syndrome (MetS) and carotid atherosclerosis.
Research design and Methods: A case-control study enrolled 513 Chinese subjects in three groups: control, MetS and obese groups. The functional TRIB3 Q84R polymorphism was genotyped among subjects undergoing carotid ultrasonography. The clinical and biochemical characteristics were determined.
Results: For individuals with the TRIB3 R84 allele, the odds ratio for developing MetS was 2.349 (P=0.018), abdominal obesity 2.351 (P=0.012), hypertriglyceridemia 2.314 (P=0.00003) and insulin resistance 1.697 (P=0.023). Likewise, the odds ratio for those with the TRIB3 R84 allele to develop thickened intima-media thickness was 2.208 (P=0.040).
Conclusions: Individuals with the functional TRIB3 Q84R polymorphism are at risk for MetS. Especially, the TRIB3 R84 allele predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia and insulin resistance.
Footnotes
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- Received January 13, 2009.
- Accepted April 13, 2009.
- Copyright © American Diabetes Association
