Reference values for continuous glucose monitoring in Chinese
- Jian Zhou, MD1,
- Hong Li, MD2,
- Xingwu Ran, MD3,
- Wenying Yang, MD, PHD4,
- Qiang Li, MD, PHD5,
- Yongde Peng, MD, PHD6,
- Yanbing Li, MD7,
- Xin Gao, MD8,
- Xiaojun Luan, MD9,
- Weiqing Wang, MD, PHD10 and
- Weiping Jia, MD, PHD (wpjia{at}sjtu.edu.cn)1
- 1, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
- 2, Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University Hangzhou, China
- 3, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China
- 4, Department of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China
- 5, Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin China
- 6, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China
- 7, Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- 8, Department of Endocrinology and Metabolism, Fudan University Affiliated Zhongshan Hospital, Shanghai, China
- 9, Department of Endocrinology and Metabolism, The First People's Hospital of Foshan, Foshan, China
- 10, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Abstract
Objective: The widespread clinical application of continuous glucose monitoring (CGM) is limited by the lack of generally accepted reference values. This multicenter study aims to establish preliminary normal reference values for CGM parameters in a sample of healthy Chinese subjects.
Research Design and Methods: A total of 434 healthy individuals with normal glucose regulation completed a 3-day period of glucose monitoring using a CGM system. The 24h mean blood glucose (24h MBG), and the percentage of time that subjects blood glucose (BG) levels were ≥ 140 mg/dl (PT140) and BG levels were ≤ 70mg/dl (PT70) within 24 hours were analyzed.
Results: There was excellent compliance of fingerstick BG values with CGM measurements for subjects. Among the 434 subjects, the daily BG varied from 76.9±11.3 mg/dl to 144.2±23.2 mg/dl. The 24h MBG, PT140 and PT70 were 104±10 mg/dl, 4.1±5.8 % and 2.4±5.3 %, respectively. As for these parameters, no significant differences were found between men and women. The 95th percentile values were adopted as the upper limits of CGM parameters, which revealed 119 mg/dl (6.6 mmol/l), for 24h MBG, 17.1% for PT140 and 11.7% for PT70.
Conclusions: We recommend a 24h MBG value lower than 119 mg/dl, PT140 less than 17% (4 hours) and PT70 less than 12% (3 hours) as normal ranges for the Chinese population.
Footnotes
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- Received January 15, 2009.
- Accepted April 14, 2009.
- Copyright © American Diabetes Association
