Changes in Basal Insulin Infusion Rates with CSII: Time until a Change in Metabolic Effect is Induced in Patients with Type 1 Diabetes

  1. Lutz Heinemann, PhD (lutz.heinemann{at},
  2. Leszek Nosek, MD1,
  3. Christoph Kapitza, MD1,
  4. Matthias-Axel Schweitzer, MD2 and
  5. Lars Krinelke, MD3
  1. 1Profil Institut für Stoffwechselforschung, D-41460 Neuss, Germany
  2. 2Roche Diagnostics, Mannheim, Germany
  3. 3Disetronic Medical Systems AG, Burgdorf, Switzerland


    Aim: Evaluation of the time required until a change in the basal insulin infusion rate with an insulin pump induces subsequent changes in the metabolic effect.

    Methods: In this euglycemic glucose-clamp study 10 male subjects with type 1 diabetes received 3 different SC insulin infusion rates (0.5, 1.0 and 2.0 U/h; for 4 h each) of insulin Lispro (IL) with insulin pumps.

    Results: An increase in insulinemia occurred within 15-30 min after changing the infusion rate. While the serum IL levels reached a steady state at the end of the infusion period, the glucose infusion rates did not always reach steady state levels with the higher infusion rates. However, an increase in the glucose consumption occurred within 30-60 min after switching the infusion rate.

    Conclusions: It requires several hours until a new steady state in the metabolic effect is achieved after a significant change in basal insulin infusion.


      • Received March 26, 2009.
      • Accepted May 15, 2009.