Serum uric acid levels improve prediction of incident Type 2 Diabetes in individuals with impaired fasting glucose: The Rancho Bernardo Study
- Caroline Kaercher Kramer, MD1,2,
- Denise von Mühlen, MD, PhD1,
- Simerjot Kaur Jassal, MD1 and
- Elizabeth Barrett-Connor, MD (ebarrettconnor{at}ucsd.edu)1
- 1Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California
- 2Division of Endocrinology, Hospital de Clinicas de Porto Alegre, RS, Brazil
Abstract
Objective: To determine whether serum uric acid (UA) predicts incident Type 2 Diabetes Mellitus (DM2) by glucose tolerance status in older community-dwelling adults.
Research design and methods: Participants without diabetes at baseline were evaluated for incident DM2 13 years later. Baseline glucose tolerance status was defined as normoglycemia, impaired fasting glucose (IFG), and impaired post-challenge glucose tolerance.
Results: 566 participants were included (mean age 63.3±8.6 yrs; 41% men). Regression models adjusted for age, sex, body mass index, diuretic use, and estimated glomerular filtration rate showed that for each 1 mg/dL increment in UA levels, incident DM2 risk increased by approximately 60%. When analyses were stratified by glucose status, UA levels independently predicted incident DM2 among participants who had IFG (OR1.75 95%CI 1.1-2.9, P=0.02).
Conclusion: UA may be a useful predictor of DM2 in older adults with IFG.
Footnotes
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- Received February 12, 2009.
- Accepted March 25, 2009.
- Copyright © American Diabetes Association
