Effects of a Higher-Carbohydrate/Lower-Fat Diet Versus a Lower-Carbohydrate/Higher-Fat-Monounsaturated Diet on Postmeal Triglyceride Concentrations and other Cardiovascular Risk Factors in Type 1 Diabetes
- Irene Strychar, EdD, RD (irene.strychar{at}umontreal.ca)1,2,3,4,
- Jeffrey S. Cohn, PhD5,
- Geneviève Renier, MD, PhD1,2,3,4,
- Michèle Rivard, PhD6,
- Nahla Aris-Jilwan, MD3,
- Hugues Beauregard, MD3,
- Sara Meltzer, MD7,
- André Belanger, MD8,
- Richard Dumas, MD8,
- Alain Ishac, MSc1,
- Farouk Radwan, MD9 and
- Jean-François Yale, MD7
- 1Research Center of the University of Montreal Hospital Center (CRCHUM)
- 2Montreal Diabetes Research Center of the CRCHUM
- 3Service of Endocrinology, Notre-Dame Hospital of the CHUM
- 4Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal
- 5Heart Research Institute, Sydney, Australia
- 6Department of Social and Preventive Medicine, University of Montreal
- 7Nutrition and Food Science Centre, Royal Victoria Hospital, McGill University Health Centre (MUHC), Montreal
- 8Laval Clinic Research Center
- 9Department of Biochemistry, Notre-Dame Hospital of the CHUM, Montreal
Abstract
Objective - To compare the effects of two eucaloric diets, a higher-carbohydrate/lower-fat versus a lower-carbohydrate/higher-fat-monounsaturated, on postmeal triglyceride (TG) concentrations and other CVD risk factors in non-obese subjects with type 1 diabetes in good glycemic control.
Methods - In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized to measure plasma TG excursions for 24-hours.
Results - There were no significant differences between groups other than decreased PAI-1 levels and increased weight in the lower-carbohydrate/higher-fat-monounsaturated diet group. During the 24-hour testing, the lower-carbohydrate/higher-fat-monounsaturated group had a lower plasma TG profile.
Conclusion - A lower-carbohydrate/higher-fat-monounsaturated diet in type 1 diabetes could offer an appropriate choice for non-obese subjects in good metabolic and weight control.
Footnotes
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- Received December 29, 2008.
- Accepted June 4, 2009.
- Copyright © American Diabetes Association
