Effects of a Higher-Carbohydrate/Lower-Fat Diet Versus a Lower-Carbohydrate/Higher-Fat-Monounsaturated Diet on Postmeal Triglyceride Concentrations and other Cardiovascular Risk Factors in Type 1 Diabetes

  1. Irene Strychar, EdD, RD (irene.strychar{at},2,3,4,
  2. Jeffrey S. Cohn, PhD5,
  3. Geneviève Renier, MD, PhD1,2,3,4,
  4. Michèle Rivard, PhD6,
  5. Nahla Aris-Jilwan, MD3,
  6. Hugues Beauregard, MD3,
  7. Sara Meltzer, MD7,
  8. André Belanger, MD8,
  9. Richard Dumas, MD8,
  10. Alain Ishac, MSc1,
  11. Farouk Radwan, MD9 and
  12. Jean-François Yale, MD7
  1. 1Research Center of the University of Montreal Hospital Center (CRCHUM)
  2. 2Montreal Diabetes Research Center of the CRCHUM
  3. 3Service of Endocrinology, Notre-Dame Hospital of the CHUM
  4. 4Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal
  5. 5Heart Research Institute, Sydney, Australia
  6. 6Department of Social and Preventive Medicine, University of Montreal
  7. 7Nutrition and Food Science Centre, Royal Victoria Hospital, McGill University Health Centre (MUHC), Montreal
  8. 8Laval Clinic Research Center
  9. 9Department of Biochemistry, Notre-Dame Hospital of the CHUM, Montreal


    Objective - To compare the effects of two eucaloric diets, a higher-carbohydrate/lower-fat versus a lower-carbohydrate/higher-fat-monounsaturated, on postmeal triglyceride (TG) concentrations and other CVD risk factors in non-obese subjects with type 1 diabetes in good glycemic control.

    Methods - In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized to measure plasma TG excursions for 24-hours.

    Results - There were no significant differences between groups other than decreased PAI-1 levels and increased weight in the lower-carbohydrate/higher-fat-monounsaturated diet group. During the 24-hour testing, the lower-carbohydrate/higher-fat-monounsaturated group had a lower plasma TG profile.

    Conclusion - A lower-carbohydrate/higher-fat-monounsaturated diet in type 1 diabetes could offer an appropriate choice for non-obese subjects in good metabolic and weight control.


      • Received December 29, 2008.
      • Accepted June 4, 2009.