IS PREHYPERTENSION A RISK FACTOR FOR THE DEVELOPMENT OF TYPE II DIABETES MELLITUS?
- David R. Mullican, MD (davemullican{at}lycos.com)1,
- Carlos Lorenzo, MD (lorenzo{at}uthscsa.edu)1 and
- Steven M. Haffner, MD1
- 1. Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center San Antonio, San Antonio, TX
Abstract
Objective: Prehypertension is associated with cardiovascular disease and insulin resistance. However, whether subjects with prehypertension have more diabetic risk is not known.
Research Design and Methods: Incident diabetes was examined in nondiabetic, normotensive participants in the San Antonio Heart Study (n = 2,767; age, 25 – 65 years; median follow-up, 7.8 years).
Results: Incident diabetes was 12.4% in subjects with prehypertension and 5.6% in subjects with normal blood pressure. The odds of incident diabetes were 2.21 greater for individuals with prehypertension than for those with normal blood pressure (95% CI: 1.63 – 2.98) after adjusting for age, sex, and ethnicity. Prehypertension was not associated with incident diabetes after the additional adjustment for BMI, IGT, insulin resistance and secretion, and family history of diabetes (OR 1.42 [0.99 – 2.02]).
Conclusion: Subjects with prehypertension are at increased risk of diabetes. Much of this risk is explained by disorders related to the insulin resistance syndrome.
Footnotes
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- Received February 18, 2009.
- Accepted July 7, 2009.
- Copyright © American Diabetes Association
