Vitamin D Levels in Subjects With and Without Type 1 Diabetes Residing in a Solar Rich Environment

  1. Lindsey Bierschenk, MS1,
  2. John Alexander, PhD1,
  3. Clive Wasserfall, MS1,
  4. Michael Haller, MD2,
  5. Desmond Schatz, MD2 and
  6. Mark Atkinson, PhD (atkinson{at}ufl.edu)1
  1. 1Department of Pathology, University of Florida, Gainesville, Florida and
  2. 2Department of Pediatrics, University of Florida, Gainesville, Florida

    Abstract

    Objective- Previous studies, largely in Northern Europe, have suggested an association between type 1 diabetes (T1D) and reduced serum 25(OH)-vitamin D levels; a concept we tested in individuals residing in a solar rich region (Florida, USA).

    Research design and methods- Serum samples from 415 individuals residing were cross-sectionally analyzed 153 controls, 46 new-onset T1D patients, 110 established T1D patients (samples ≥ 5 months from diagnosis), and 106 of their first-degree relatives.

    Results- 25(OH)-vitamin D levels (median ng/ml; range; IQR) were similar amongst controls (20.1; below detection (bd)-163.5; 13.0-37.4), new-onset T1D patients (21.2; bd-48.6; 12.2-30.2), established T1D patients (23.2; bd-263.8; 13.8-33.9), and first-degree relatives (22.15; bd-59.9; 12.7-33.1) (P=0.87). Mean 25(OH)-vitamin D levels were less than the optimal WHO level of 30 ng/ml in all study groups.

    Conclusions- Reduced serum 25(OH)-vitamin D levels were not specifically associated with T1D. The uniform suboptimal 25(OH)-vitamin D levels, despite residence in a zone with abundant sunshine, support additional dietary vitamin D fortification practices.

    Footnotes

      • Received June 15, 2009.
      • Accepted July 30, 2009.

    This Article

    1. Diabetes Care
    1. All Versions of this Article:
      1. dc09-1089v1
      2. 32/11/1977 most recent