From Genetic Risk Awareness to Overt Type 1 Diabetes: Parental Stress in a Placebo-Controlled Prevention Trial

  1. Eszter Goldstein, MD1,2,
  2. Robert Hermann, MD, PHD1,3,
  3. Timo J. Renfors, PHD4,5,
  4. Kirsti M. Näntö-Salonen, MD, PHD (kirsti.nanto-salonen{at}tyks.fi)1,
  5. Tapio Korhonen, PHD6,
  6. Maarit Kärkkäinen, MHSci1,7,
  7. Riitta K. Veijola, MD, PHD8,
  8. Mikael Knip, MD, PHD9,10,
  9. Tuula T. Simell, PHD1 and
  10. Olli G. Simell, MD, PHD1
  1. 1Department of Pediatrics, University of Turku, Turku, Finland
  2. 2Department of Psychiatry, Healthcare Center, Pécs, Hungary
  3. 3CellScreen Applied Biomedical Research Center, Budapest, Hungary
  4. 4Department of Psychology, University of Joensuu, Joensuu, Finland
  5. 5North Karelia Center for Public Health, Joensuu, Finland
  6. 6Department of Psychology, University of Turku, Turku, Finland
  7. 7Stadia Helsinki Polytechnic, Helsinki, Finland
  8. 8Department of Pediatrics, University of Oulu, Oulu, Finland
  9. 9Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
  10. 10Department of Pediatrics, Tampere University Hospital, Tampere, Finland

    Abstract

    Objective To evaluate the psychological burden of parents facing increasing risk of type 1 diabetes in their children.

    Research design and methods In the population-based Type 1 Diabetes Prediction and Prevention study (DIPP), newborn infants with HLA-DQB1 -conferred diabetes risk were enrolled in sequential analyses of diabetes-associated autoantibodies. Those persistently positive for at least two autoantibodies were recruited to a randomized double-blinded intervention trial. The experience of stress in parents of 664 children was measured using Parenting Stress Index self-report inventory.

    Results While diagnosis of diabetes increased parental stress, the appearance of autoantibodies or participation in the intervention trial did not. Mothers had higher stress levels than fathers. Single parenthood and chronically ill family members increased parental stress.

    Conclusions Parental stress was not increased by notification of autoantibody positivity or by participation in an intervention trial. Other demanding family conditions contributed to the experience of stress.

    Footnotes

      • Received March 4, 2009.
      • Accepted September 4, 2009.

    This Article

    1. Diabetes Care
    1. All Versions of this Article:
      1. dc09-0423v1
      2. 32/12/2181 most recent