Serum levels of the adipokine chemerin in relation to renal function
- Dörte Pfau, MS1,
- Anette Bachmann, MD1,
- Ulrike Lössner, BS1,
- Jürgen Kratzsch, PhD2,
- Matthias Blüher, MD1,
- Michael Stumvoll, MD1 and
- Mathias Fasshauer, MD (mathias.fasshauer{at}medizin.uni-leipzig.de)1
- 1: University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
- 2: University of Leipzig, Institute of Laboratory Medicine, 04103 Leipzig, Germany
Abstract
Objective: To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared to controls with a glomerular filtration rate (GFR) above 50 ml/min.
Research Design and Methods: Chemerin was quantified by ELISA in control (n=60) and CD (n=60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups.
Results: Median serum chemerin levels were more than 2-fold higher in CD patients (542.2 μg/l) as compared to subjects with a GFR above 50 ml/min (254.3 μg/l) (p < 0.001). Furthermore, glomerular filtration rate as assessed by the original Modification of Diet in Renal Disease formula independently predicted circulating chemerin concentrations in multiple regression analyses in both control subjects (p < 0.05) and patients on CD (p < 0.01).
Conclusions: We demonstrate that markers of renal function are independently related to circulating chemerin levels.
Footnotes
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- Received July 23, 2009.
- Accepted October 7, 2009.
- Copyright © American Diabetes Association
