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Marine Omega-3 Fatty Acid Intake: Associations with Cardiometabolic Risk and Response to Weight Loss Intervention in The Look AHEAD Study

  1. L. Maria Belalcazar, MD (lmbelalc{at}utmb.edu)1,2,
  2. David M. Reboussin, PhD3,
  3. Steven M. Haffner, MD4,
  4. Rebecca S. Reeves, DrPh2,
  5. Dawn C. Schwenke, PhD5,
  6. Ron C. Hoogeveen, PhD2,
  7. F. Xavier Pi-Sunyer, MD6,
  8. Christie M. Ballantyne, MD2,7 and
  9. for the Look AHEAD (Action for Health in Diabetes) Obesity, Inflammation and Thrombosis Research Group
  1. From the1Department of Medicine, University of Texas Medical Branch, Galveston, Texas
  2. 2Department of Medicine, Baylor College of Medicine, Houston, Texas
  3. 3Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina
  4. 4Department of Medicine, University of Texas Health Science Center, San Antonio, Texas
  5. 5Arizona State University, Tempe, Arizona
  6. 6Department of Medicine, Columbia University, St. Luke's-Roosevelt Hospital, New York, New York
  7. 7The Methodist Hospital, Houston, Texas

    Abstract

    Objective- To examine usual marine omega-3 fatty acid (mO-3FA) intake in persons with diabetes, its association with adiposity, lipid and glucose control and its changes with behavioral lifestyle intervention for weight loss.

    Research design and methods- Cross-sectional and one-year longitudinal analyses were performed on 2397 Look AHEAD (LA) participants. LA is a cardiovascular-outcome trial evaluating the effects of intensive lifestyle intervention (ILI) for weight loss in overweight/obese subjects with type 2 diabetes.

    Results- Baseline mO-3FA intake was 162 ± 138 mg/day. It was inversely associated with triglycerides (B = −0.41, p <0.001) and weakly with HDL (B = 4.14, p = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with ILI (p <0.001).

    Conclusions- mO-3FA intake in LA participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.

    Footnotes

      • Received July 7, 2009.
      • Accepted September 21, 2009.

    This Article

    1. Published online before print October 19, 2009, doi: 10.2337/dc09-1235 Diabetes Care October 19, 2009
    1. » Abstract
    2. Full Text (PDF)
    3. Online-Only Appendix
    4. All Versions of this Article:
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