Associations of Serum Concentrations of 25-Hydroxyvitamin D and Parathyroid Hormone with Surrogate Markers of Insulin Resistance among U.S. Adults without Physician-Diagnosed Diabetes: National Health and Nutrition Examination Survey, 2003-2006
- Guixiang Zhao, MD, PhD (GZhao{at}cdc.gov),
- Earl S. Ford, MD, MPH and
- Chaoyang Li, MD, PhD
- Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia
Abstract
Objective- To examine whether concentrations of serum 25-hydroxyvitamin D (25[OH]D) and parathyroid hormone (PTH) are associated with surrogate markers of insulin resistance (IR) in U.S. adults without physician-diagnosed diabetes.
Research design and methods- Cross-sectional data (n=3,206) from the 2003-2006 National Health and Nutrition Examination Survey were analyzed.
Results- The age-adjusted prevalence of hyperinsulinemia, high homeostatic model assessment-IR, high glycohemoglobin, and fasting and 2-hour hyperglycemia decreased linearly across quintiles of 25(OH)D but increased linearly across quintiles of PTH (except for a quadratic trend for fasting hyperglycemia). After extensive adjustment for potential confounders, the relationships between 25(OH)D and the markers of IR and 2-hour hyperglycemia persisted. Only hyperinsulinemia was positively associated with PTH (P<0.05).
Conclusions- Among U.S. adults without physician-diagnosed diabetes, low concentrations of serum 25(OH)D were associated with markers of IR. The role of PTH in IR deserves further investigation.
Footnotes
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- Received May 20, 2009.
- Accepted October 13, 2009.
- Copyright © American Diabetes Association
