Glycated albumin and glycated hemoglobin are differently influenced by endogenous insulin secretion in patients with type 2 diabetes mellitus
- Masafumi Koga, MD, PhD (koga_m{at}kich.itami.hyogo.jp)1,
- Jun Murai, MD1,
- Hiroshi Saito, MD, PhD1 and
- Soji Kasayama, MD, PhD2
- From the 1Department of Internal Medicine, Kinki Central Hospital, Itami, Hyogo
- the 2Department of Medicine, Nissay Hospital, Osaka, Japan
Abstract
Objective: Glycated albumin (GA) relative to glycated hemoglobin (HbA1C) is a useful marker of short-term glycemic control. We investigated whether endogenous insulin secretion in type 2 diabetes mellitus (T2DM) has different effects on GA and HbA1C levels.
Research Design and Methods: HbA1C, GA and GA/HbA1C ratio were compared in 202 T2DM patients by type of treatment. Effect of beta-cell function determined by homeostasis model assessment (HOMA-%β) on GA/HbA1C ratio was examined. In addition, GA/HbA1C ratio was compared between T2DM patients and 16 patients with type 1 diabetes mellitus (T1DM).
Results: In T2DM patients, GA/HbA1C ratio was significantly higher in those treated with insulin than in those treated with diet or oral hypoglycemic agents. HOMA-%β showed a significant inverse correlation with GA/HbA1C ratio. This ratio was higher in T1DM patients than in T2DM patients.
Conclusions: In diabetic patients with decreased insulin secretion, serum GA levels are higher relative to HbA1C.
Footnotes
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- Received June 2, 2009.
- Accepted October 14, 2009.
- Copyright © American Diabetes Association
