Labile Hemogloblin A1c is Inversely Correlated with the Hemoglobin Glycation Index in Children with Type 1 Diabetes
- Stuart A. Chalew, M.D. (schale{at}lsuhsc.edu)1,
- James M. Hempe, PhD.2,
- Robert J. McCarter, ScD3 and
- Jeanine Ory-Ascani, MS2
- 1 Pediatric Endocrinology, Department of Pediatrics, Louisiana State University Health Sciences Center and the Children's Hospital of New Orleans, New Orleans, LA
- 2Children's Hospital of New Orleans, Research Institute
- 3Children's National Medical Center, Bioinformatics Unit, Washington, D.C
Abstract
Objective: We hypothesized that labile HbA1c (LHbA1c), is directly correlated with stable HbA1c (SHbA1c) and between-patient differences in SHbA1c which are independent of mean blood glucose (MBG).
Research design and method: We measured SHbA1c, LHbA1c, MBG and a single clinic capillary glucose (CCG) from 152 pediatric patients with type 1 diabetes. Patients were grouped as High, Moderate, or Low glycators by Hemoglobin Glycation Index.
Results: LHbA1c and SHbA1c were correlated with CCG and MBG. LHbA1c was not correlated with SHbA1c (r=0.06, p=0.453). LHbA1c level was significantly associated with glycator group status (p<0.0019) and CCG (p<0.0001). Adjusted LHbA1c levels were highest in the Low HGI patients and lowest in the High HGI group.
Conclusion: A conventional model of SHbA1c being directly correlated with LHbA1c concentration was not confirmed. Between patient differences in SHbA1c at the same MBG may be due to complex intracellular factors influencing formation of SHbA1c from LHbA1c.
Footnotes
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- Received December 12, 2008.
- Accepted November 12, 2009.
- Copyright © American Diabetes Association
