Increased Carotid Intima Media Thickness as a Predictor of the Presence and Extent of Abnormal Myocardial Perfusion in Type 2 Diabetes Mellitus
- Roxana Djaberi, MD1,
- Joanne D Schuijf, PHD1,
- J Wouter Jukema, MD, PHD1,2,
- Ton J Rabelink, MD, PHD3,
- Marcel P Stokkel, MD, PHD4,
- Jan W Smit, MD, PHD5,
- Eelco J de Koning, MD, PHD3 and
- Jeroen J Bax, MD, PHD (J.J.Bax{at}LUMC.nl)1
- 1Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
- 2Eindhoven Laboratory of Experimental Vascular Medicine, the Netherlands
- 3Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands
- 4Department of Nuclear Medicine, Leiden University Medical Center, Leiden, the Netherlands
- 5Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Abstract
Objective: Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease remains a challenge. We evaluated the potential of carotid intima media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population.
Research design and methods: CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as ≥75thpercentile of reference values.
Results: Increased CIMT was an independent predictor of the extent of abnormal perfusion (P<0.001). In patients with increased CIMT as compared to patients with normal CIMT, abnormal perfusion (75%vs9%) and severely abnormal perfusion (28%vs3%) were observed more frequently.
Conclusions: Increased CIMT was significantly related to the presence and extent of abnormal myocardial perfusion. Assessment of CIMT may be useful to identify asymptomatic patients with type 2 diabetes at higher risk for coronary artery disease.
Footnotes
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- Received July 16, 2009.
- Accepted November 2, 2009.
- Copyright © American Diabetes Association
