Inflammation markers and metabolic characteristics of subjects with one-hour plasma glucose levels

  1. Gianluca Bardini, MD, PhD,
  2. Ilaria Dicembrini, MD,
  3. Barbara Cresci, MD and
  4. Carlo Maria Rotella, MD (c.rotella{at}dfc.unifi.it)
  1. Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Italy

    Abstract

    Objective: To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes (pre-DM).

    Research Design And Methods: A cohort of 1062 subjects was enrolled. After oral glucose load (OGTT), we compared NGT and pre-DM subjects above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leucocytes count (WBC) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda Index), were determined.

    Results: NGT and pre-DM patients 1hPG>155 mg/dl showed a significant increase of inflammatory markers and lipid ratios (for all, p<0.05). In age-sex-BMI-adjusted analysis, 1hPG is associated with a significant higher WBC count and fibrinogen (p<0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects below 1hPG (p<0.01).

    Conclusions: Elevated 1hPG in NGT and pre-DM subjects is associated to subclinical inflammation, high lipid ratios and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new “marker” for cardiovascular risk.

    Footnotes

      • Received July 22, 2009.
      • Accepted November 2, 2009.

    This Article

    1. Diabetes Care
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