Prevalence of Type 1 Diabetes auto-antibodies (GADA, IA2, IAA) in overweight and obese children

  1. Valentina M Cambuli, MD1,
  2. Michela Incani, BSc1,
  3. Efisio Cossu, MD1,
  4. Tiziana Congiu, MD1,
  5. Francesca Scano, MD1,
  6. Sabrina Pilia, MD2,
  7. Federica Sentinelli, BSc PhD1,
  8. Claudio Tiberti, ATA3,
  9. M. Gisella Cavallo, MD PhD4,
  10. Sandro Loche, MD2 and
  11. Marco G Baroni, MD PhD (marcobaroni{at}
  1. 1Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
  2. 2Pediatric Endocrine Unit, Regional Hospital for Microcitemia, Cagliari, Italy
  3. 3Department of Clinical Sciences, Policlinico Umberto I, University “La Sapienza” of Rome, Rome, Italy
  4. 4Department of Clinical and Medical Therapy, University “La Sapienza” of Rome, Rome, Italy


Background: Little is known on the prevalence of beta-cells auto-antibodies in children with excess body weight.

Research Design and Methods: The prevalence of type 1 diabetes auto-antibodies and its relation with hyperglycemia was analyzed in 686 overweight/obese children and adolescents. All children underwent OGTT and anti-GAD, anti-IA2 and anti-IAA auto-antibodies were measured. Auto-antibodies prevalence was evaluated in 107 normal weight children for comparison.

Results: A single auto-antibody was present in 2.18% overweight/obese and in 1.86% normal weight subjects (p=NS). Post-load glycemia was significantly higher in antibody-positive children (133±69.9 vs. 105.4±17.7 mg/dl; p<0.0001) compared to auto-antibody-negative subjects. No difference in auto-antibodies distribution was seen when our cohort was stratified by age, sex, SDS-BMI, pubertal stage and HOMA-IR.

Conclusions: The 2.18% prevalence of type 1 diabetes auto-antibodies is very similar to that reported in non obese children. This study provided evidence that excess body weight and insulin-resistance do not influence auto-antibodies frequency.


    • Received August 23, 2009.
    • Accepted December 21, 2009.

This Article

  1. Diabetes Care
  1. All Versions of this Article:
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