ATLANTIC DIP: The Impact Of Obesity On Pregnancy Outcome In Glucose Tolerant Women

doi:10.2337/dc09-0911

ATLANTIC DIP: The Impact Of Obesity On Pregnancy Outcome In Glucose Tolerant Women

Lisa A Owens, MD¹,
Eoin P O'Sullivan, MD¹,
Breeda Kirwan, RN¹,
Gloria Avalos, MSC¹,
Geraldine Gaffney, MD RCOG²,
Fidelma Dunne, MD PhD (Fidelma.dunne{at}nuigalway.ie)¹ and
For the ATLANTIC DIP COLLABORATORS

¹Department of Medicine, National University of Ireland, Galway, Ireland
²Department of Obstetrics and Gynaecology, National University of Ireland, Galway, Ireland

Abstract

Objective: A prospective study of impact of obesity on pregnancy outcome in glucose tolerant women.

Research Design and Methods: The Irish Atlantic Diabetes in Pregnancy network advocates universal screening for gestational diabetes. Women with normoglycaemia and a recorded booking body mass index (BMI) were included. Maternal and infant outcomes correlated with booking BMI are reported.

Results: 2329 women fulfilled the criteria. Caesarean deliveries increased in OW (OR1.57, 95%CI,1.24-1.98), OB (OR 2.65,95%-CI,2.03-3.46) women. Hypertensive disorders increased in OW (OR 2.30,95%-CI,1.55-3.40, OB (OR 3.29,95%-CI,2.14-5.05) women. Reported miscarriages increased in OB (OR 1.4,95%-CI,1.11-1.77) women. Mean birth-weight was 3.46kg NBMI, 3.54kg OW, 3.62kg OB (p<0.01) mothers. Macrosomia occurred in 15.5%, 21.4%, 27.8% of babies of NBMI, OW, OB mothers (p<0.01). Shoulder dystocia occurred in 4% (>4Kg) compared to 0.2% (<4kg) babies (p<0.01). Congenital malformation risk increased for OB (OR 2.47,95%-CI, 1.09-5.60) women.

Conclusions: OW and OB glucose tolerant women have greater adverse pregnancy outcomes.