Variation of Interstitial Glucose Measurements Assessed by Continuous Glucose Monitors in Healthy, Non-obese, Non-diabetic Individuals

  1. Dongyuan Xing, M.P.H.

Abstract

Aim: To characterize glucose levels during daily living using continuous glucose monitors (CGM) in non-diabetic individuals.

Research Design and Methods: Seventy-four healthy, non-obese children, adolescents, and adults aged 9-65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days.

Results: Sensor glucose concentrations were 71-120 mg/dL for 91% of the day. Sensor values were ≤60 or >140 for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P=0.009) and were slightly lower during the night than day (95 mg/dL versus 99 mg/dL, P<0.001).

Conclusions: Glucose values ≤60 mg/dL and >140 mg/dL, measured with CGM, are uncommon in healthy, non-diabetic individuals. CGM may be useful to evaluate glucose tolerance in non-diabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.

Footnotes

    • Received October 26, 2009.
    • Accepted February 25, 2010.

This Article

  1. Diabetes Care
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