Association of A1c Levels with Vitamin D Status in U.S. Adults: Data from the National Health and Nutrition Examination Survey

  1. Stephen Geraci, MD6
  1. 1Medical Service, GV (Sonny) Montgomery VA Medical Center, Jackson, MS
  2. 2Division of Geriatrics, Department of Medicine, University of Mississippi, Jackson, MS
  3. 3Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL
  4. 4Section of Health Promotion Research, University of Illinois at Chicago, Chicago, IL
  5. 5Research Health Scientist, Center for Management of Complex Chronic Care, Jesse Brown VA Medical Center, Chicago, IL
  6. 6Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Mississippi, Jackson, MS

Abstract

Objective - Data relating vitamin D status with indices of glucose homeostasis as manifested by A1c in the U.S. adult population are few.

Research Design and Methods - We examined the association between serum 25-OH vitamin D and A1c levels in 9773 adults (age ≥ 18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders.

Results - Serum 25-OH vitamin D levels were inversely associated with A1c levels in subjects age 35 to 74 years (p=0.0045) and those who did not report a history of diabetes mellitus (p=0.0282).

Conclusions - These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1c levels for vitamin D insufficiency should be considered.

Footnotes

    • Received November 20, 2010.
    • Accepted February 26, 2010.

This Article

  1. Diabetes Care
  1. All Versions of this Article:
    1. dc09-2150v1
    2. 33/6/1236 most recent