Dietary phylloquinone and menaquinones intake and risk of type 2 diabetes

  1. Yvonne T van der Schouw, PhD1
  1. 1 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  2. 2 Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
  3. 3 Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands

Abstract

Objectives: To investigate whether dietary phylloquinone and menaquinones intake are related to risk of type 2 diabetes.

Research Design & Methods: We used data of a prospective cohort study in 38,094 Dutch men and women, aged 20 to 70 years. Dietary phylloquinone and menaquinones intake was assessed using a validated food frequency questionnaire. Diabetes cases were mainly ascertained via self report and verified against medical records.

Results: During 10.3 years follow-up, 918 incident diabetes cases were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (p=0.08) with a reduced risk of type 2 diabetes with a hazard ratio of 0.81 (95%-CI: 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (p=0.038) with risk of type 2 diabetes was observed with a hazard ratio of 0.93 (0.87-1.00) for each 10 μg increment in the multivariate model.

Conclusion: This study shows that both phylloquinone and menaquinones intake may be associated with a reduced risk of type 2 diabetes.

Footnotes

    • Received December 17, 2009.
    • Accepted April 22, 2010.

This Article

  1. Diabetes Care
  1. All Versions of this Article:
    1. dc09-2302v1
    2. 33/8/1699 most recent