Dietary phylloquinone and menaquinones intake and risk of type 2 diabetes
- Joline WJ Beulens, PhD (J.Beulens{at}umcutrecht.nl)1,2,
- Daphne L van der A, PhD3,
- Diederick E. Grobbee, MD1,
- Ivonne Sluijs, MSc1,
- Annemieke MW Spijkerman, PhD2 and
- Yvonne T van der Schouw, PhD1
- 1 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
- 2 Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
- 3 Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
Abstract
Objectives: To investigate whether dietary phylloquinone and menaquinones intake are related to risk of type 2 diabetes.
Research Design & Methods: We used data of a prospective cohort study in 38,094 Dutch men and women, aged 20 to 70 years. Dietary phylloquinone and menaquinones intake was assessed using a validated food frequency questionnaire. Diabetes cases were mainly ascertained via self report and verified against medical records.
Results: During 10.3 years follow-up, 918 incident diabetes cases were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (p=0.08) with a reduced risk of type 2 diabetes with a hazard ratio of 0.81 (95%-CI: 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (p=0.038) with risk of type 2 diabetes was observed with a hazard ratio of 0.93 (0.87-1.00) for each 10 μg increment in the multivariate model.
Conclusion: This study shows that both phylloquinone and menaquinones intake may be associated with a reduced risk of type 2 diabetes.
Footnotes
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- Received December 17, 2009.
- Accepted April 22, 2010.
- Copyright © American Diabetes Association
