Mixing Insulin Aspart With Detemir Does Not Affect Glucose Excursion In Children With Type 1 Diabetes Mellitus

  1. Rubina A. Heptulla, MD (heptulla{at}bcm.edu)2
  1. 1Department of Pediatrics-Endocrinology Section, Nemours Children's Clinic, Jacksonville, Florida
  2. 2Department of Pediatrics-Endocrinology and Metabolism Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas

Abstract

Objective: We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes mellitus.

Research Design and Methods: 14 children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or with Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 hours of each study.

Results: 48-hour AUC (mmol.hour/L), M-value and MAGE (mmol/L) for Study A vs. B were 457 ± 70 vs. 469 ± 112 (p = 0.58), 39.67 ± 15.37 vs. 39.75 ± 9.69 (p = 0.98), and 6.35 ± 1.92 vs. 5.98 ± 0.92 (p = 0.42), respectively.

Conclusions: Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections, in children with type 1 diabetes.

Footnotes

    • Received January 26, 2010.
    • Accepted May 18, 2010.

    This Article

    1. Diabetes Care
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