Polyendocrinopathy in children, adolescents and young adults with type 1 diabetes. A multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss-database

  1. on behalf of the DPV-Initiative of the German working group for pediatric diabetology and the German BMBF Competency Network for Diabetes Mellitus
  1. From the 1Department of Pediatrics, Technische Universität München, Munich, Germany
  2. 2Department of Pediatrics, Medical University of Graz, Graz, Austria
  3. 3Department of Pediatrics, Hannover Medical School, Hannover, Germany
  4. 4 Department of Pediatrics, Medical University of Innsbruck, Austria
  5. 5 Department of Pediatrics, Otto-von Guericke University Magdeburg, Magdeburg, Germany; and the
  6. 6 Department of Epidemiology, University of Ulm, Ulm, Germany

Abstract

Objective To investigate diabetes-specific autoantibodies and additional autoimmune phenomena in a very large cohort of young patients with type 1 diabetes (T1D).

Research Design and methods Data from 28,671 patients < 30 years with T1D from 242 specialized centres in Germany and Austria were analyzed.

Results At least one Beta-cell-antibody was present in 81.6% of patients. ß-cell-Ab-negative patients were significantly younger at diabetes onset (p<0.0001). 19.6% had positive thyroid antibodies with female predominance (62 %, p<0.0001). Antibodies to tissue transglutaminase were present in 10.7%, with a significantly longer duration of diabetes (p<0.0001). Parietal cell antibodies were found in 283 patients, associated with older age (p<0.001), and adrenal antibodies were present in 94 patients. In 575 patients, at least 3 different autoimmune phenomena were present.

Conclusions Thyroid autoimmunity and antibodies suggestive for celiac disease are the most prevalent additional immune phenomena in T1D. Parietal/ adrenal antibodies are rare.

Footnotes

    • Received March 1, 2010.
    • Accepted June 7, 2010.

    This Article

    1. Diabetes Care
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