Extended Family History of Diabetes and Autoimmune Diseases in Children With and Without Type 1 Diabetes

  1. Veijola Riitta, MD, PHD (riitta.veijola{at}
  1. 1 Department of Pediatrics, University of Oulu, Oulu, Finland
  2. 2 Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
  3. 3 Department of Pediatrics, Tampere University Hospital, Tampere, Finland


Objective - To determine the extended family history of diabetes or autoimmune diseases in families with and without children having type 1 diabetes.

Research design and methods – 300 case families and 381 control families were interviewed using structured questionnaires.

Results - The proportion of case children having at least one relative with type 1 diabetes outside the nuclear family was higher than that of control children (50.3% vs. 31.8%; p<0.001). The proportions of cases and controls having relatives with type 2 diabetes or gestational diabetes were similar. Other autoimmune diseases occurred more frequently among the cases (9.7% vs. 1.1%, p<0.001), in the case nuclear families (22.0% vs. 12.9%, p=0.002) and in relatives outside the case nuclear family (72.0% vs. 62.2%, p=0.007).

Conclusion - Type 1 diabetes and autoimmune diseases not only cluster in the nuclear families of children with type 1 diabetes but are also overrepresented in their extended families.

  • Received June 8, 2010.
  • Accepted September 20, 2010.

This Article

  1. Diabetes Care
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