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Original Research
Metabolic Syndrome and Onset of Depressive Symptoms in the Elderly
Tasnime N. Akbaraly, Marie-Laure Ancelin, Isabelle Jaussent, Craig Ritchie, Pascale Barberger-Gateau, Carole Dufouil, Mika Kivimaki, Claudine Berr and Karen Ritchie
Diabetes Care 2011 Feb; DC_101644. https://doi.org/10.2337/dc10-1644
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Abstract

OBJECTIVE Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age groups in a large, general elderly population.

RESEARCH DESIGN AND METHODS This was a prospective cohort study of 4,446 men and women aged 65–91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups.

RESULTS After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02–2.95) odds for new-onset depressive symptoms in the youngest age group (65–70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age groups.

CONCLUSIONS Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65–70 years.

  • Received August 25, 2010.
  • Accepted January 22, 2011.
  • © 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Diabetes Care: 42 (3)

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March 2019
Volume 42, Issue 3

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Metabolic Syndrome and Onset of Depressive Symptoms in the Elderly
Tasnime N. Akbaraly, Marie-Laure Ancelin, Isabelle Jaussent, Craig Ritchie, Pascale Barberger-Gateau, Carole Dufouil, Mika Kivimaki, Claudine Berr, Karen Ritchie
Diabetes Care Feb 2011, DC_101644; DOI: 10.2337/dc10-1644

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Metabolic Syndrome and Onset of Depressive Symptoms in the Elderly
Tasnime N. Akbaraly, Marie-Laure Ancelin, Isabelle Jaussent, Craig Ritchie, Pascale Barberger-Gateau, Carole Dufouil, Mika Kivimaki, Claudine Berr, Karen Ritchie
Diabetes Care Feb 2011, DC_101644; DOI: 10.2337/dc10-1644
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© 2019 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.