One-Third of Patients Have Evidence for an Additional Autoimmune Disease at Type 1 Diabetes Diagnosis
- Taylor M. Triolo, BS1,
- Taylor K. Armstrong, BS1,
- Kim McFann, PHD2,
- Liping Yu, MD1,
- Marian J. Rewers, MD, PHD1,
- Georgeanna J. Klingensmith, MD1,
- George S. Eisenbarth, MD, PHD1 and
- Jennifer M. Barker, MD1
- 1Barbara Davis Center for Childhood Diabetes, Aurora, Colorado
- 2Colorado Biostatistics Consortium, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado
- ↵Corresponding author: Taylor M. Triolo, .
OBJECTIVE We sought to define the prevalence of nonislet, organ-specific autoantibodies at diagnosis of type 1 diabetes and to determine the prevalence of comorbid autoimmune diseases.
RESEARCH DESIGN AND METHODS Children (n = 491) diagnosed with type 1 diabetes at the Barbara Davis Center for Childhood Diabetes were screened for autoimmune thyroid disease (thyroid peroxidase autoantibodies [TPOAb]), celiac disease (tissue transglutaminase autoantibodies [TTGAb]), and Addison disease (21-hydroxylase autoantibodies [21OHAb]).
RESULTS Of the 491 children, 161 had at least one nonislet autoantibody, and of these, 122 (24.8%) were positive for TPOAb, and 15 of the 122 (12.3%) had autoimmune thyroid disease. There were 57 (11.6%) who were positive for TTGAb, of whom 14 (24.6%) had celiac disease. Five (1.0%) were positive for 21OHAb, of whom one had Addison disease.
CONCLUSIONS Many autoantibody-positive subjects present with additional autoimmune disorders. Detection of these autoantibodies at type 1 diabetes onset may prevent complications associated with delayed diagnosis of these disorders.
- Received September 10, 2010.
- Accepted February 21, 2011.
- © 2011 by the American Diabetes Association.
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