One-Third of Patients Have Evidence for an Additional Autoimmune Disease at Type 1 Diabetes Diagnosis

  1. Jennifer M. Barker, MD1
  1. 1Barbara Davis Center for Childhood Diabetes, Aurora, Colorado
  2. 2Colorado Biostatistics Consortium, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado
  1. Corresponding author: Taylor M. Triolo, taylor.triolo{at}


OBJECTIVE We sought to define the prevalence of nonislet, organ-specific autoantibodies at diagnosis of type 1 diabetes and to determine the prevalence of comorbid autoimmune diseases.

RESEARCH DESIGN AND METHODS Children (n = 491) diagnosed with type 1 diabetes at the Barbara Davis Center for Childhood Diabetes were screened for autoimmune thyroid disease (thyroid peroxidase autoantibodies [TPOAb]), celiac disease (tissue transglutaminase autoantibodies [TTGAb]), and Addison disease (21-hydroxylase autoantibodies [21OHAb]).

RESULTS Of the 491 children, 161 had at least one nonislet autoantibody, and of these, 122 (24.8%) were positive for TPOAb, and 15 of the 122 (12.3%) had autoimmune thyroid disease. There were 57 (11.6%) who were positive for TTGAb, of whom 14 (24.6%) had celiac disease. Five (1.0%) were positive for 21OHAb, of whom one had Addison disease.

CONCLUSIONS Many autoantibody-positive subjects present with additional autoimmune disorders. Detection of these autoantibodies at type 1 diabetes onset may prevent complications associated with delayed diagnosis of these disorders.

  • Received September 10, 2010.
  • Accepted February 21, 2011.

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This Article

  1. Diabetes Care
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