Basal Insulin Requirement Is ∼30% of the Total Daily Insulin Dose in Type 1 Diabetic Patients, Who Use the Insulin Pump
- Akio Kuroda, MD1,
- Hideaki Kaneto, MD1,
- Tetsuyuki Yasuda, MD1,
- Munehide Matsuhisa, MD2,
- Kazuyuki Miyashita, MD1,
- Noritaka Fujiki, MD1,
- Keiko Fujisawa, MD1,
- Tsunehiko Yamamoto, MD1,
- Mitsuyoshi Takahara, MD1,
- Fumie Sakamoto, MD1,
- Taka-aki Matsuoka, MD1 and
- Iichiro Shimomura, MD1
- 1Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
- 2Diabetes Clinical Research and Development Center, Tokushima University, Tokushima, Japan
- ↵Corresponding author: Akio Kuroda, .
OBJECTIVE To investigate the basal insulin requirement in total daily insulin dose in Japanese type 1 diabetic patients, who use the insulin pump.
RESEARCH DESIGN AND METHODS The basal insulin requirement in 35 type 1 diabetic patients without detectable C-peptide using the insulin pump (Paradigm 712) was investigated during 2–3 weeks of hospitalization. The patients were served diabetic diets of 25–30 kcal/kg ideal body weight. Each meal omission was done to confirm stable blood glucose levels within 30 mg/dL variance until the next meal. Target blood glucose level was set at 100 mg/dL before each meal and 150 mg/dL at 2 h after each meal.
RESULTS Total daily insulin dose was 31.6 ± 8.5 units, and total basal insulin requirement was 8.7 ± 2.9 units, which was 27.7 ± 6.9% of the total daily dose.
CONCLUSIONS Basal insulin requirement is ∼30% of the total daily dose in Japanese type 1 diabetic patients, who use the insulin pump.
- Received November 15, 2010.
- Accepted February 14, 2011.
- © 2011 by the American Diabetes Association.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.