Evaluation of Nonfasting Tests to Screen for Childhood and Adolescent Dysglycemia
- Joyce M. Lee, MD, MPH1,2⇓,
- Achamyeleh Gebremariam, MS2,
- En-Ling Wu, BA3,
- Jennifer LaRose, BS4 and
- James G. Gurney, PHD5
- 1Division of Pediatric Endocrinology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
- 2Child Health Evaluation and Research Unit, Division of General Pediatrics, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
- 3University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan
- 4Transportation Research Institute, University of Michigan, Ann Arbor, Michigan
- 5Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, Tennessee
- Corresponding author: Joyce M. Lee, .
OBJECTIVE To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes).
RESEARCH DESIGN AND METHODS This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10–17 years. Subjects came for two visits to a clinical research unit. For visit one, they arrived fasting and a 2-h glucose tolerance test and HbA1c and fructosamine testing were performed. For visit two, they arrived nonfasting and had a random plasma glucose, a 1-h 50-g nonfasting glucose challenge test (1-h GCT), and urine dipstick performed. The primary end point was dysglycemia (fasting plasma glucose ≥100 mg/dL or a 2-h postglucose ≥140 mg/dL). Test performance was assessed using receiver operating characteristic (ROC) curves and calculations of area under the ROC curve.
RESULTS Approximately one-half of children were female, 59% were white, and 30% were black. There were 99 (39%) cases of prediabetes and 3 (1.2%) cases of diabetes. Urine dipstick, HbA1c (area under the curve [AUC] 0.54 [0.47–0.61]), and fructosamine (0.55 [0.47–0.63]) displayed poor discrimination for identifying children with dysglycemia. Both random glucose (0.66 [0.60–0.73]) and 1-h GCT (AUC 0.68 [0.61–0.74]) had better levels of test discrimination than HbA1c or fructosamine.
CONCLUSIONS HbA1c had poor discrimination, which could lead to missed cases of dysglycemia in children. Random glucose or 1-h GCT may potentially be incorporated into clinical practice as initial screening tests for prediabetes or diabetes and for determining which children should undergo further definitive testing.
- Received May 2, 2011.
- Accepted August 30, 2011.
- © 2011 by the American Diabetes Association.
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