Low Water Intake and Risk for New-Onset Hyperglycemia

  1. for the D.E.S.I.R. Study Group
  1. 1Université Paris–Diderot, Paris 7, Paris, France
  2. 2Département d'Endocrinologie, Diabétologie et Nutrition, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris France
  3. 3INSERM U695, Paris, France
  4. 4INSERM U872, Centre de Recherche des Cordeliers, Paris, France
  5. 5Université Pierre et Marie Curie, Paris, France
  6. 6Université Paris Descartes, Paris, France
  7. 7INSERM CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over the Life Course, Villejuif, France
  8. 8Université Paris 11, UMRS 1018, Villejuif, France
  9. 9Institut Inter-Régional pour la Santé, La Riche, France
  10. 10Département d’Hypertension Artérielle, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
  1. Corresponding author: Ronan Roussel, ronan.roussel{at}


OBJECTIVE Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes.

RESEARCH DESIGN AND METHODS Participants were 3,615 middle-aged men and women, with normal baseline fasting glycemia (FG), who were recruited in a 9-year follow-up study. Odds ratios (Ors) and 95% CIs for the incidence of hyperglycemia (FG ≥6.1 mmol/L or treatment for diabetes) were calculated according to daily water intake classes based on a self-administered questionnaire.

RESULTS During follow-up, there were 565 incident cases of hyperglycemia. After adjustment for confounding factors, ORs (95% CIs) for hyperglycemia associated with classes of water intake (<0.5 L, n = 677; 0.5 to <1.0 L, n = 1,754; and >1.0 L, n = 1,184) were 1.00, 0.68 (0.52–0.89), and 0.79 (0.59–1.05), respectively (P = 0.016).

CONCLUSIONS Self-reported water intake was inversely and independently associated with the risk of developing hyperglycemia.

  • Received April 6, 2011.
  • Accepted September 4, 2011.

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  1. Diabetes Care
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