Risk of Parkinson Disease Onset in Patients With Diabetes
A 9-year population-based cohort study with age and sex stratifications
- Yu Sun, MD, PHD1,
- Ya-Hui Chang, MSC2,
- Hua-Fen Chen, MD, MSC3,4,
- Ying-Hwa Su, PHD5,
- Hui-Fang Su, PHD6 and
- Chung-Yi Li, PHD2,7⇓
- 1Department of Neurology, En Chu Kong Hospital, Sanxia District, New Taipei City, Taiwan
- 2Department and Graduate Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
- 3Department of Endocrinology, Far Eastern Memorial Hospital, Ban-Ciao District, New Taipei City, Taiwan
- 4School of Medicine, Fu-Jen Catholic University, Hsin-Chuang District, New Taipei City, Taiwan
- 5Department of Nursing, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
- 6Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan
- 7Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan
- Corresponding author: Chung-Yi Li, .
OBJECTIVE We retrospectively assessed the age- and sex-specific incidence and relative risk of Parkinson disease (PD) in Taiwan’s diabetic population.
RESEARCH DESIGN AND METHODS Study cohort included 603,416 diabetic patients and 472,188 nondiabetic control subjects. Incidence rate and relative risk of PD (ICD-9-CM 332.0) were evaluated.
RESULTS The incidence of PD was 3.59 and 2.15 per 10,000 person-years for the diabetic and control group, respectively, representing a covariate adjusted hazard ratio (HR) of 1.61 (95% CI 1.56–1.66), which was substantially reduced to 1.37 (1.32–1.41) after adjusting for medical visits. Diabetes was associated with a significantly elevated risk of PD in all sex and age stratifications except in young women, with the highest HR noted for young men aged 21–40 years (2.10 [1.01–4.42]), followed by women aged 41–60 (2.05 [1.82–2.30]) and >60 years (1.65 [1.58–1.73]).
CONCLUSIONS Diabetes is associated with an increased risk of PD onset in a Chinese population, and the relation is stronger in women and younger patients.
- Received August 9, 2011.
- Accepted January 19, 2012.
- © 2012 by the American Diabetes Association.
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