The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes
A 24-month, double-blind, randomized, placebo-controlled trial
- David A. Fraser, PHD1⇓,
- Lien M. Diep, MSC2,
- Inger Anette Hovden, MD, PHD3,
- Kristian B. Nilsen, MD, PHD3,4,
- Kari Anne Sveen, MD1,
- Ingebjørg Seljeflot, PHD5,6 and
- Kristian F. Hanssen, MD, PHD6,7
- 1Diabetes Research Centre, Oslo University Hospital, Oslo, Norway
- 2Oslo University Hospital, Oslo, Norway
- 3Department of Neurology, Section for Clinical Neurophysiology, Oslo University Hospital-Ullevål, Oslo, Norway
- 4Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
- 5Center for Clinical Heart Research, Department of Cardiology B, Oslo University Hospital, Oslo, Norway
- 6Faculty of Medicine, University of Oslo, Norway
- 7Department of Endocrinology, Oslo University Hospital, Oslo, Norway
- Corresponding author: David A. Fraser, .
OBJECTIVE To study the effects of long-term oral benfotiamine supplementation on peripheral nerve function and soluble inflammatory markers in patients with type 1 diabetes.
RESEARCH DESIGN AND METHODS The study randomly assigned 67 patients with type 1 diabetes to receive 24-month benfotiamine (300 mg/day) or placebo supplementation. Peripheral nerve function and levels of soluble inflammatory variables were assessed at baseline and at 24 months.
RESULTS Fifty-nine patients completed the study. Marked increases in whole-blood concentrations of thiamine and thiamine diphosphate were found in the benfotiamine group (both P < 0.001 vs. placebo). However, no significant differences in changes in peripheral nerve function or soluble inflammatory biomarkers were observed between the groups.
CONCLUSION Our findings suggest that high-dose benfotiamine (300 mg/day) supplementation over 24 months has no significant effects upon peripheral nerve function or soluble markers of inflammation in patients with type 1 diabetes.
- Received September 30, 2011.
- Accepted January 23, 2012.
- © 2012 by the American Diabetes Association.
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