Metabolic Effects of Replacing Sucrose by Isomaltulose in Subjects With Type 2 Diabetes
A randomized double-blind trial
- Stefanie Brunner, MSC1,
- Ines Holub, DIPL-TROPH2,
- Stephan Theis, PHD2,
- Andrea Gostner, PHD, MD3,
- Ralph Melcher, MD3,
- Petra Wolf, DIPL-STAT4,
- Ulrike Amann-Gassner, PHD1,
- Wolfgang Scheppach, MD5 and
- Hans Hauner, MD1⇓
- 1Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany and ZIEL-Research Center for Nutrition and Food Science, Nutritional Medicine Unit, Technische Universität München, Freising, Germany
- 2Suedzucker AG Mannheim/Ochsenfurt, Obrigheim/Pfalz, Germany
- 3Department of Medicine II, Division of Gastroenterology, University of Wuerzburg, Wuerzburg, Germany
- 4Institute for Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany
- 5Juliusspital Wuerzburg, Department of Medicine, Wuerzburg, Germany
- Corresponding author: Hans Hauner, .
S.B. and I.H. contributed equally to this work.
OBJECTIVE To test the hypothesis that replacement of sucrose with isomaltulose in sweet foods and beverages improves metabolic control in patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS One hundred ten patients with type 2 diabetes were randomized to receive sweet foods containing either 50 g/day isomaltulose or sucrose for 12 weeks as part of their habitual diet under free-living conditions. HbA1c at 12 weeks was the primary outcome parameter.
RESULTS In the final analysis comprising 101 patients, isomaltulose did not significantly affect HbA1c at 12 weeks (sucrose: 7.39 ± 0.78%, isomaltulose: 7.24 ± 0.76%; regression coefficient [b]: 0.02 [95% CI: −0.21 to 0.25], P = 0.844). Triglycerides at 12 weeks were significantly lower in the isomaltulose versus the sucrose group (b: 34.01 [6.59–61.44], P = 0.016). Other secondary parameters did not significantly differ between groups.
CONCLUSIONS Isomaltulose did not influence glycemic control assessed as HbA1c in type 2 diabetes under free-living conditions but was associated with lower triglyceride levels.
- Received August 5, 2011.
- Accepted February 13, 2012.
- © 2012 by the American Diabetes Association.
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