Metabolic Effects of Replacing Sucrose by Isomaltulose in Subjects With Type 2 Diabetes
A randomized double-blind trial
- Stefanie Brunner, MSC1,
- Ines Holub, DIPL-TROPH2,
- Stephan Theis, PHD2,
- Andrea Gostner, PHD, MD3,
- Ralph Melcher, MD3,
- Petra Wolf, DIPL-STAT4,
- Ulrike Amann-Gassner, PHD1,
- Wolfgang Scheppach, MD5 and
- Hans Hauner, MD1⇓
- 1Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany and ZIEL-Research Center for Nutrition and Food Science, Nutritional Medicine Unit, Technische Universität München, Freising, Germany
- 2Suedzucker AG Mannheim/Ochsenfurt, Obrigheim/Pfalz, Germany
- 3Department of Medicine II, Division of Gastroenterology, University of Wuerzburg, Wuerzburg, Germany
- 4Institute for Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany
- 5Juliusspital Wuerzburg, Department of Medicine, Wuerzburg, Germany
- Corresponding author: Hans Hauner, hans.hauner{at}tum.de.
-
S.B. and I.H. contributed equally to this work.
Abstract
OBJECTIVE To test the hypothesis that replacement of sucrose with isomaltulose in sweet foods and beverages improves metabolic control in patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS One hundred ten patients with type 2 diabetes were randomized to receive sweet foods containing either 50 g/day isomaltulose or sucrose for 12 weeks as part of their habitual diet under free-living conditions. HbA1c at 12 weeks was the primary outcome parameter.
RESULTS In the final analysis comprising 101 patients, isomaltulose did not significantly affect HbA1c at 12 weeks (sucrose: 7.39 ± 0.78%, isomaltulose: 7.24 ± 0.76%; regression coefficient [b]: 0.02 [95% CI: −0.21 to 0.25], P = 0.844). Triglycerides at 12 weeks were significantly lower in the isomaltulose versus the sucrose group (b: 34.01 [6.59–61.44], P = 0.016). Other secondary parameters did not significantly differ between groups.
CONCLUSIONS Isomaltulose did not influence glycemic control assessed as HbA1c in type 2 diabetes under free-living conditions but was associated with lower triglyceride levels.
- Received August 5, 2011.
- Accepted February 13, 2012.
- © 2012 by the American Diabetes Association.
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