Health-Related Quality of Life Among German Youths With Early-Onset and Long-Duration Type 1 Diabetes

  1. Joachim Rosenbauer, MD1
  1. 1Institute of Biometry and Epidemiology, German Diabetes Center (DDZ), Leibniz Center at the Heinrich Heine University, Düsseldorf, Germany
  2. 2Medical Psychology Unit, Hannover Medical School, Hannover, Germany
  3. 3Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
  1. Corresponding author: Anna Stahl, anna.stahl{at}ddz.uni-duesseldorf.de.

Abstract

OBJECTIVE To evaluate self- and parent-reports of general health status and health-related quality of life (QoL) in children and adolescents with early-onset and long-lasting type 1 diabetes compared with the general population in Germany.

RESEARCH DESIGN AND METHODS A total of 629 subjects aged 11 to 17 years, with a type 1 diabetes onset occurring from age 0 to 4 years during the years 1993–1999, and their parents, completed questionnaires, including the generic KINDL-R Questionnaire for Measuring Health-Related Quality of Life in Children and Adolescents, revised version, to assess QoL. The comparison group (n = 6,813) was a representative sample from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) study. Regression analyses were conducted using sociodemographic and health-related covariates.

RESULTS Intensified insulin therapy was used to treat 93% of children and adolescents with type 1 diabetes. They reported “excellent” general health as often as peers (adjusted OR 0.83 [95% CI 0.66–1.04] for an “excellent” rating), but the parent-rated general health was worse than that in the general population (OR 0.60 [0.48–0.74]). The patients reported increased self-esteem (adjusted difference β = 4.39 [SE 0.82]; P < 0.001) and well-being at school (β = 3.41 [0.77]; P < 0.001) but lower well-being within their families (β = –2.42 [0.80]; P = 0.002). The self- and parent-reported total QoL did not differ between the patient group and the general population. The adjusted difference (SE) between the two samples in total QoL was β = 0.89 (0.52; P = 0.087) in the self-reports and β = –0.98 (0.53; P = 0.066) in the parent-reports.

CONCLUSIONS Compared with the general population, the QoL and general health status were not impaired among those aged 11–17 years with early-onset type 1 diabetes, despite the challenges of modern therapy.

  • Received December 15, 2011.
  • Accepted March 29, 2012.

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This Article

  1. Diabetes Care
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