Curcumin Extract for Prevention of Type 2 Diabetes
- Somlak Chuengsamarn, MD1,2⇓,
- Suthee Rattanamongkolgul, MD3,
- Rataya Luechapudiporn, PHD4,
- Chada Phisalaphong, PHD5 and
- Siwanon Jirawatnotai, PHD6,7
- 1Division of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand
- 2Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts
- 3Department of Preventive and Social Medicine, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand
- 4Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
- 5Research and Development Institute, Thai Government Pharmaceutical Organization, Bangkok, Thailand
- 6Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon pratom, Thailand
- 7Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts
- Corresponding author: Somlak Chuengsamarn, .
OBJECTIVE To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetes population.
RESEARCH DESIGN AND METHODS This randomized, double-blinded, placebo- controlled trial included subjects (n = 240) with criteria of prediabetes. All subjects were randomly assigned to receive either curcumin or placebo capsules for 9 months. To assess the T2DM progression after curcumin treatments and to determine the number of subjects progressing to T2DM, changes in β-cell functions (homeostasis model assessment [HOMA]-β, C-peptide, and proinsulin/insulin), insulin resistance (HOMA-IR), anti-inflammatory cytokine (adiponectin), and other parameters were monitored at the baseline and at 3-, 6-, and 9-month visits during the course of intervention.
RESULTS After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05). The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P < 0.001) and higher adiponectin (22.46 vs. 18.45; P < 0.05) when compared with the placebo group.
CONCLUSIONS A 9-month curcumin intervention of a prediabetes population significantly lowered the number of prediabetic individuals who eventually developed T2DM. In addition, the curcumin treatment appeared to improve overall function of β-cells, with very minor adverse effects. Therefore, this study demonstrated that the curcumin intervention in a prediabetes population may be beneficial.
- Received January 18, 2012.
- Accepted May 9, 2012.
- © 2012 by the American Diabetes Association.
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