IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated to a General Celiac-Specific Lower Immune Response in Comparison with Nondiabetic Celiac Patients at Diagnosis
- Claudio Tiberti, ACD1,
- Francesca Panimolle, BS1,
- Margherita Bonamico, MD2,
- Blegina Shashaj, MD2,
- Tiziana Filardi, MD1,
- Federica Lucantoni, BS2,
- Raffaella Nenna, MD2,
- Francesco Costantino, MD2,
- Andrea Lenzi, MD3 and
- Susanna Morano, MD1
- 1Department of Internal Medicine, University of Rome “Sapienza,” Rome, Italy
- 2Department of Pediatrics, University of Rome “Sapienza,” Rome, Italy
- 3Department of Physiopathology, University of Rome “Sapienza,” Rome, Italy
- Corresponding author: Susanna Morano, .
OBJECTIVE To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to nondiabetic patients at celiac disease (CD) diagnosis.
RESEARCH DESIGN AND METHODS IgA anti-transglutaminase autoantibody (IgA-tTGAb) detection in 654 new-onset DM1 sera. IgA-tTGAb+ DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies and results compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis.
RESULTS A total of 12.8% DM1 sera were IgA-tTGAb+, with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1% ≤18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb+ DM1 compared with nondiabetic CD patients.
CONCLUSIONS Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis.
- Received November 9, 2011.
- Accepted April 26, 2012.
- © 2012 by the American Diabetes Association.
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