IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated to a General Celiac-Specific Lower Immune Response in Comparison with Nondiabetic Celiac Patients at Diagnosis

  1. Susanna Morano, MD1
  1. 1Department of Internal Medicine, University of Rome “Sapienza,” Rome, Italy
  2. 2Department of Pediatrics, University of Rome “Sapienza,” Rome, Italy
  3. 3Department of Physiopathology, University of Rome “Sapienza,” Rome, Italy
  1. Corresponding author: Susanna Morano, susanna.morano{at}


OBJECTIVE To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to nondiabetic patients at celiac disease (CD) diagnosis.

RESEARCH DESIGN AND METHODS IgA anti-transglutaminase autoantibody (IgA-tTGAb) detection in 654 new-onset DM1 sera. IgA-tTGAb+ DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies and results compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis.

RESULTS A total of 12.8% DM1 sera were IgA-tTGAb+, with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1% ≤18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb+ DM1 compared with nondiabetic CD patients.

CONCLUSIONS Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis.

  • Received November 9, 2011.
  • Accepted April 26, 2012.

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  1. Diabetes Care
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