Cardiovascular Events After Bariatric Surgery in Obese Subjects With Type 2 Diabetes
- Stefano Romeo, MD, PHD1⇓,
- Cristina Maglio, MD1,
- Maria Antonella Burza, MD1,
- Carlo Pirazzi, MD1,
- Kajsa Sjöholm, PHD1,
- Peter Jacobson, MD, PHD1,
- Per-Arne Svensson, PHD1,
- Markku Peltonen, PHD2,
- Lars Sjöström, MD, PHD1 and
- Lena M.S. Carlsson, MD, PHD1
- 1Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- 2Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
- Corresponding author: Stefano Romeo, .
L.S. and L.M.S.C. contributed equally to this work.
OBJECTIVE Obese individuals with type 2 diabetes have an increased risk of cardiovascular disease. The effect of bariatric surgery on cardiovascular events in obese individuals with type 2 diabetes remains to be determined. The Swedish Obese Subjects (SOS) study is a prospective, controlled intervention study that examines the effects of bariatric surgery on hard end points. The aim of the present study was to examine the effect of bariatric surgery on cardiovascular events in the SOS study participants with type 2 diabetes.
RESEARCH DESIGN AND METHODS All SOS study participants with type 2 diabetes at baseline were included in the analyses (n = 345 in the surgery group and n = 262 in the control group). Mean follow-up was 13.3 years (interquartile range 10.2–16.4 years) for all cardiovascular events.
RESULTS Bariatric surgery was associated with a reduced myocardial infarction incidence (38 events among the 345 subjects in the surgery group vs. 43 events among the 262 subjects in the control group; log-rank P = 0.017; adjusted hazard ratio (HR) 0.56 [95% CI 0.34–0.93]; P = 0.025). No effect of bariatric surgery was observed on stroke incidence (34 events among the 345 subjects in the surgery group vs. 24 events among the 262 subjects in the control group; log-rank P = 0.852; adjusted HR 0.73 [0.41–1.30]; P = 0.29). The effect of surgery in reducing myocardial infarction incidence was stronger in individuals with higher serum total cholesterol and triglycerides at baseline (interaction P value = 0.02 for both traits). BMI (interaction P value = 0.12) was not related to the surgery outcome.
CONCLUSIONS Bariatric surgery reduces the incidence of myocardial infarction in obese individuals with type 2 diabetes. Preoperative BMI should be integrated with metabolic parameters to maximize the benefits of bariatric surgery.
- Received January 30, 2012.
- Accepted May 30, 2012.
- © 2012 by the American Diabetes Association.
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