The Use of an Automated, Portable, Glucose Control System for Overnight Glucose Control in Adolescents and Young Adults With Type 1 Diabetes
- Michael J. O'Grady, MBBCH, MRCPI1,2,
- Adam J. Retterath, BSC2,
- D. Barry Keenan, PHD3,
- Natalie Kurtz, PHD3,
- Martin Cantwell, BSC3,
- Glenn Spital, BSC3,
- Michael N. Kremliovsky, PHD3,
- Anirban Roy, PHD3,
- Elizabeth A. Davis, PHD, FRACP1,2,4,
- Timothy W. Jones, MD, FRACP1,2,4⇓ and
- Trang T. Ly, MBBS, FRACP1,2,4
- 1Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
- 2Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
- 3Medtronic Minimed, Northridge, California
- 4School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia
- Corresponding author: Tim Jones, .
OBJECTIVE A key milestone in progress towards providing an efficacious and safe closed-loop artificial pancreas system for outpatient use is the development of fully automated, portable devices with fault detection capabilities to ensure patient safety. The ability to remotely monitor the operation of the closed-loop system would facilitate future physician–supervised home studies.
RESEARCH DESIGN AND METHODS This study was designed to investigate the efficacy and safety of a fully automated, portable, closed-loop system. The Medtronic Portable Glucose Control System (PGCS) consists of two subcutaneous glucose sensors, a control algorithm based on proportional-integral-derivative with insulin feedback operating from a BlackBerry Storm smartphone platform, Bluetooth radiofrequency translator, and an off-the-shelf Medtronic Paradigm Veo insulin pump. Participants with type 1 diabetes using insulin pump therapy underwent two consecutive nights of in-clinic, overnight, closed-loop control after a baseline open-loop assessment.
RESULTS Eight participants attended for 16 overnight studies. The PGCS maintained mean overnight plasma glucose levels of 6.4 ± 1.7 mmol/L (115 ± 31 mg/dL). The proportion of time with venous plasma glucose <3.9, between 3.9 and 8 (70 and 144 mg/dL), and >8 mmol/L was 7, 78, and 15%, respectively. The proportion of time the sensor glucose values were maintained between 3.9 and 8 mmol/L was greater for closed-loop than open-loop (84.5 vs. 46.7%; P < 0.0001), and time spent <3.3 mmol/L was also reduced (0.9 vs. 3%; P < 0.0001).
CONCLUSIONS These results suggest that the PGCS, an automated closed-loop device, is safe and effective in achieving overnight glucose control in patients with type 1 diabetes.
- Received April 21, 2012.
- Accepted May 26, 2012.
- © 2012 by the American Diabetes Association.
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