Moderate-Intensity Physical Activity Ameliorates the Breast Cancer Risk in Diabetic Women
- Gabriela Torres-Mejía, PHD1,
- Angélica Angeles-Llerenas, MSC1⇓,
- Carolina Ortega-Olvera, MSC1,
- Eduardo Lazcano-Ponce, PHD1,
- Elad Ziv, PHD2,3,
- José Pulido-Rodríguez, MD4,
- Manuel de Jesús García-Solis, MD4,
- Efrén Murillo-Zamora, MSC1,6,
- Julia Vázquez-Lara, MD5 and
- Isabelle Romieu, PHD7
- 1National Institute of Public Health, Center for Population Health Research, Cuernavaca, Morelos, Mexico
- 2Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics, San Francisco, California
- 3Department of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, San Francisco, California
- 4Metropolitan Hospital “Dr. Bernardo Sepúlveda” Monterrey, Nuevo León, Mexico
- 5Hospital No. 23 of Gynecology, IMSS, Monterrey, Nuevo León, Mexico
- 6Hospital No. 4, IMSS, Tecomán, Colima, Mexico
- 7Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
- Corresponding author: Angélica Angeles-Llerenas, aangelica{at}insp.mx.
Abstract
OBJECTIVE To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women.
RESEARCH DESIGN AND METHODS A population-based case-control study was conducted using 1,000 incident case subjects and 1,074 control subjects. Blood samples and information on health, diet, physical activity, and anthropometric measurements were obtained.
RESULTS The association between diabetes and BC risk decreased with increasing tertiles of moderate-intensity physical activity (odds ratio [OR] = 4.9 [95% CI 2.3–10.8]; 3.0 [1.3–6.9]; and 1.0 [0.1–9.2] respectively, for each tertile) (test for interaction = 0.04). Compared with the women in the lowest tertiles, increased risk was observed in those premenopausal women with the highest serum C-peptide, IGF-1, and IGF-1 binding protein 3 levels.
CONCLUSIONS Moderate-intensity physical activity can substantially ameliorate the increased BC risk in diabetic women.
- Received December 5, 2011.
- Accepted May 25, 2012.
- © 2012 by the American Diabetes Association.
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