Reduction in Carotid Intima-Media Thickness After Pancreatic Islet Transplantation in Patients With Type 1 Diabetes
- Kirstie K. Danielson, PHD1,2⇓,
- Betul Hatipoglu, MD3,
- Katie Kinzer, BS2,
- Bruce Kaplan, MD4,
- Joan Martellotto, PHD2,
- Meirigeng Qi, MD, PHD2,
- Alessandra Mele, MD2,
- Enrico Benedetti, MD2 and
- José Oberholzer, MD2
- 1Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois
- 2Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, Illinois
- 3Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, Ohio
- 4Department of Medicine, University of Arizona, Tucson, Arizona
- Corresponding author: Kirstie K. Danielson, .
OBJECTIVE Determine the impact of islet transplantation on carotid intima-media thickness (CIMT), a marker for atherosclerosis, in type 1 diabetes without kidney disease.
RESEARCH DESIGN AND METHODS Consecutive case series of 15 adults (mean age [SD], 49 years [10 years]; 87% female) with type 1 diabetes for ≥5 years (mean duration [SD], 30 years [12 years]; mean HbA1c [SD], 7.2% [0.9%]), without kidney disease, presenting with severe hypoglycemic unawareness to undergo allogeneic pancreatic islet transplant(s) (one to three each) in a phase 1/2 and 3 clinical trial. Current follow-up ranges from 1 to 5 years (2005–2011). CIMT of the common and internal carotid arteries was measured before and every 12–16 months after the first transplant (two to six CIMTs each) by one ultrasonographer and one blinded reader. CIMT was analyzed as change from baseline to 12- and 50-month follow-up; a combined CIMT score was calculated as the sum of the standardized IMT scores (SD units [SDs]) of both arteries.
RESULTS All patients achieved insulin independence after one to three transplants. CIMT decreased at 12 months (n = 15) for the common carotid (−0.058 mm; P = 0.006) and combined score (−1.28 SDs; P = 0.004). In those with 50-month follow-up (n = 7), the decrease in the combined score continued from 12 (−1.59 SDs; P = 0.04) to 50 months (−0.77 SDs; P = 0.04). During follow-up, the decreasing slope of change in CIMT was associated with decreasing slopes of change in HbA1c, lipoproteins, and cardiovascular/inflammatory markers.
CONCLUSIONS Islet transplantation may ameliorate diabetes-related atherosclerosis through improved glycemic control consequent to restoring endogenous insulin secretion, and optimal lipid management posttransplant also contributes.
- Received April 9, 2012.
- Accepted August 2, 2012.
- © 2012 by the American Diabetes Association.
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