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Original Research
Safety and Efficacy of Sitagliptin Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes
Guillermo E. Umpierrez, Roma Gianchandani, Dawn Smiley, Sol Jacobs, David H. Wesorick, Christopher Newton, Farnoosh Farrokhi, Limin Peng, David Reyes, Sangeeta Lathkar-Pradhan and Francisco Pasquel
Diabetes Care 2013 Jul; DC_130277. https://doi.org/10.2337/dc13-0277
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Abstract

OBJECTIVE This study investigated the safety and efficacy of sitagliptin (Januvia) for the inpatient management of type 2 diabetes (T2D) in general medicine and surgery patients.

RESEARCH DESIGN AND METHODS In this pilot, multicenter, open-label, randomized study, patients (n = 90) with a known history of T2D treated with diet, oral antidiabetic agents, or low total daily dose of insulin (≤0.4 units/kg/day) were randomized to receive sitagliptin alone or in combination with glargine insulin (glargine) or to a basal bolus insulin regimen (glargine and lispro) plus supplemental (correction) doses of lispro. Major study outcomes included differences in daily blood glucose (BG), frequency of treatment failures (defined as three or more consecutive BG >240 mg/dL or a mean daily BG >240 mg/dL), and hypoglycemia between groups.

RESULTS Glycemic control improved similarly in all treatment groups. There were no differences in the mean daily BG after the 1st day of treatment (P = 0.23), number of readings within a BG target of 70 and 140 mg/dL (P = 0.53), number of BG readings >200 mg/dL (P = 0.23), and number of treatment failures (P > 0.99). The total daily insulin dose and number of insulin injections were significantly less in the sitagliptin groups compared with the basal bolus group (both P < 0.001). There were no differences in length of hospital stay (P = 0.78) or in the number of hypoglycemic events between groups (P = 0.86)

CONCLUSIONS Results of this pilot indicate that treatment with sitagliptin alone or in combination with basal insulin is safe and effective for the management of hyperglycemia in general medicine and surgery patients with T2D.

  • Received February 1, 2013.
  • Accepted May 11, 2013.
  • © 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Diabetes Care: 41 (5)

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May 2018
Volume 41, Issue 5

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Safety and Efficacy of Sitagliptin Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes
Guillermo E. Umpierrez, Roma Gianchandani, Dawn Smiley, Sol Jacobs, David H. Wesorick, Christopher Newton, Farnoosh Farrokhi, Limin Peng, David Reyes, Sangeeta Lathkar-Pradhan, Francisco Pasquel
Diabetes Care Jul 2013, DC_130277; DOI: 10.2337/dc13-0277

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Safety and Efficacy of Sitagliptin Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes
Guillermo E. Umpierrez, Roma Gianchandani, Dawn Smiley, Sol Jacobs, David H. Wesorick, Christopher Newton, Farnoosh Farrokhi, Limin Peng, David Reyes, Sangeeta Lathkar-Pradhan, Francisco Pasquel
Diabetes Care Jul 2013, DC_130277; DOI: 10.2337/dc13-0277
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© 2018 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.