OBJECTIVES This study investigated if inositol in a combination of myo-inositol and D-Chiro-inositol would prevent gestational diabetes mellitus (GDM) in women with a family history of diabetes.
RESEARCH DESIGN AND METHODS This was a randomized controlled trial that examined whether inositol from the first antenatal visit prevents GDM. The trial was carried out in a single-center tertiary referral center. Women with a family history of diabetes were enrolled at the first antenatal visit. They were randomized to the intervention group, who received a combination of 1,100 mg myo-inositol, 27.6 g D-Chiro inositol, and 400 mcg folic acid, or to the control group, who received 400 mcg folic acid only. All women had an oral glucose tolerance test between 24 and 28 weeks gestation. The primary end point was the incidence of GDM. Statistical analysis was carried out using SPSS Statistical Package version 20.
RESULTS Two hundred forty women, 120 in each arm, were recruited between January 2014 and July 2015. There were no differences in characteristics between the groups. The incidence of GDM was 23.3% (n = 28) in the intervention group compared with 18.3% (n = 22) in the control group (P = 0.34). The mean fasting plasma glucose at the glucose tolerance test was 81 mg/dL in both groups.
CONCLUSIONS Commencing an inositol combination in early pregnancy did not prevent GDM in women with a family history of diabetes. Further studies are required to examine whether inositol supplements at varying doses may prevent GDM.
- Received November 19, 2016.
- Accepted February 23, 2017.
- © 2017 by the American Diabetes Association.