Table 3

Odds ratio (95% CI) for the percentage of Look AHEAD cohort achieving clinically meaningful changes in CVD risk factors

Clinical criteriaGained >2%Stable Gained ≤2 or lost <2%Lost ≥2 to <5%Lost ≥5 to <10%Lost ≥10 to <15%Lost ≥15%
5 mmHg decrease in SBP0.86 (0.70–1.06)1.01.24 (1.02–1.50)1.56 (1.27–1.91)2.29 (1.79–2.93)2.65 (2.00–3.50)
5 mmHg decrease in DBP1.03 (0.83–1.28)1.01.05 (0.86–1.28)1.48 (1.20–1.82)1.60 (1.25–2.06)2.39 (1.81–3.16)
20 mg/dL decrease in glucose1.13 (0.87–1.46)1.01.75 (1.40–2.19)3.24 (2.57–4.09)4.07 (3.09–5.36)7.92 (5.78–10.85)
0.05% decrease in HbA1c1.17 (0.91–1.50)1.01.80 (1.44–2.24)3.52 (2.81–4.40)5.44 (4.15–7.13)10.02 (7.31–13.73)
5 mg/dL increase in HDL0.88 (0.71–1.11)1.01.13 (0.93–1.39)1.69 (1.37–2.07)2.30 (1.80–2.93)4.34 (3.30–5.72)
5 mg/dL increase in HDL (not on medications)0.79 (0.54–1.15)1.00.99 (0.71–1.39)1.52 (1.08–2.15)2.54 (1.68–3.82)5.27 (3.36–8.27)
10 mg/dL decrease in LDL1.17 (0.95–1.45)1.01.05 (0.86–1.29)1.34 (1.09–1.64)1.26 (0.98–1.62)1.34 (1.02–1.78)
10 mg/dL decrease in LDL (not on medications)1.39 (0.97–1.99)1.00.97 (0.69–1.36)1.41 (1.00–2.00)1.28 (0.83–1.96)1.52 (0.96–2.41)
40 mg/dL decrease in triglycerides0.80 (0.60–1.06)1.01.46 (1.14–1.87)2.20 (1.71–2.83)3.99 (2.97–5.35)7.18 (5.19–9.93)
  • Significant odds ratios are shown in boldface.